RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
PDF herunterladen
Synfacts 2011(3): 0292-0292
DOI: 10.1055/s-0030-1259471
DOI: 10.1055/s-0030-1259471
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New YorkChromium-Catalyzed Enantioselective Alkynylation of Aldehydes
D. L. Usanov, H. Yamamoto*
The University of Chicago, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
16. Februar 2011 (online)
Significance
The preparation of enantiomerically pure propargyl alcohols is an important task since they are useful and versatile building blocks in organic synthesis. Herein, the authors describe the first example of an asymmetric chromium-catalyzed alkynylation of aldehydes 1 with 1-haloalkynes 2 towards chiral propargylic alcohols of type 3 in high yields and good to excellent enantioselectivities (up to 92% ee).